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[14] Zepbound returns as an "additional preferred option" from October 1, 2026 (Wegovy keeps its preferred status) [14] Eligible commercial patients: as little as $25/month with the Lilly savings card (excludes Medicare/Medicaid/TRICARE/VA) this is a manufacturer discount, not your plan copay [14] CVS did not specify formulary tier/copay
This reflects receptor adaptation and tolerability management , not limitations in pharmacologic potency
Clinical trials, including STEP 4 and SURMOUNT-4 (see the semaglutide and tirzepatide sections below) support the idea that discontinuing medications at the patients desired goal weight may lead to weight regain, and therefore is typically not recommended
They may feel stronger later than expected
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